LDN-27219 PROTEIN KINASE TARGETING OPTIONS

One particular notably intriguing compound is LDN-27219. Whilst most tTG inhibitors are designed to bind into the protein crosslinking Lively web page, LDN-27219 as a substitute binds on the nucleotide binding pocket from the enzyme though it can be in its shut-condition conformation, and stabilizes that conformation to stop crosslinking activity.s